Faculty of Health, Medicine and Life Sciences

Module Information
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MBS1301  - Nutrition, Physical Activity and Metabolism; Fundamental Aspects

Period 3: from 8-1-2024 to 9-3-2024
Coordinator: Kallen, C. van der
ECTS credits: 10
Language of instruction: English

Publication dates timetable/results in the Student Portal

Deadline publication timetable
The date on which the timetable of this module is available: 15-12-2023

Deadline publication final result
The date on which the final grade of this module is available: 29-3-2023

Resit booking

Exam booking for a test in current academic year (resit)
You will be booked automatically for the resit in one of our resit periods. You may check our calenders to find out which modules can be retaken and when: https://intranet.maastrichtuniversity.nl/nl/fhml-studenten/studieverloop/wanneer-wat
As of one week before the resit test takes place, you can check in Student Portal if you are booked correctly: Student Portal > My Courses > More actions. The test will also be visible in your time table.

Exam booking for a test from a previous academic year (exam only)
All students who have not passed the test for this module in a previous academic year, will be booked automatically for the test during the regular block period. You will be enrolled in the new course in Canvas but not scheduled for a tutorial group and other educational activities. If you do not wish to participate in this test at the end of the regular block period please de-register via askFHML.

Resit date: 9-7-2024

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Course information

Description: EN:

This course aims to provide a solid fundament to understand the mechanisms underlying the metabolic aberrations that are commonly observed in many of the current no-communicable disorders. A proper understanding of these mechanisms is essential to design, optimize, apply and examine interventions that aim to alleviate the metabolic aberrations and to slow down disease progression. To this end this course will encompass studying the major systems involved in human (nutritional) physiology and metabolism. This ranges from the process of nutrient uptake across the gastrointestinal tract to cell and organ specific routes for conversion of macromolecules into their oxidizable derivatives.


The pivotal role of intermediary metabolism and (subcellular) energy sensing and of metabolites and small circulatory hormone like peptides (e.g., adipocytokines) will be studied. This course will, therefore, further deal with the important notion of inter-organ cross-talk and designates how to convey this knowledge to the development of whole body metabolic control. It will provide a basis for targeted treatment of aberrations in (energy) homeostasis, substrate metabolism, inter-organ cross talk as related to macronutrients (fat, carbohydrates, and protein) and specific nutritional components. Special attention will be given to the metabolic routes that are altered in acute and chronic metabolic disorders and the putative role of the biological clock herein. More specifically, these disorders are discussed in relation to the role of nutrition in preventing and treating these disorders.


Nutrients play a role in the regulation of gene transcription, translation, and signal transduction. This, of course, affects cellular pathways. If these pathways become disturbed, it may ultimately result in disease, which may require special dietary interventions. In this course, the molecular basis and cellular mechanisms by which nutrients affect metabolic control is studied at the cellular level. 

Goals: EN:
Course Objectives

    1. Describe the function and interaction of the listed organs in nutritional physiology and physical activity: Liver, stomach and gut, adipose tissue, brain and muscle.

    2. Explain and predict the uptake, storage, degradation, and the intermediary metabolism of nutrients and substrates on organ, cellular and subcellular level.

    3. Characterize the transport, uptake and metabolism of macro- and micronutrients.

    4. Explain competition and selection of nutrients and substrate flux in pre- and post -prandial states.

    5. Explain competition and selection of nutrients, and substrate flux during rest and exhaustive exercise in a trained and untrained state.

    6. Apply the concepts above to healthy and chronic disease scenarios.

    7. Characterize metabolic aberrations in chronic disease and come-up personalized interventions for intervention.

    8. Argue the translational aspects of nutritional and physical activity related model systems.

    9. Argue the scientific basis for policy making on human nutrition, physical activity, and dietary guidelines.

10. Critically evaluate recent manuscripts discussing aspects of health related to nutritional status and physical activity.

Key words:
Literature: This is the link to Keylinks, our online reference list.  
Teaching methods:
  • Assignment(s)
  • Work in workgroup(s)
  • Lecture(s)
  • Paper(s)
  • Problem Based Learning
  • Presentation(s)
  • Research
  • Working visit(s)
Assessments methods:
  • Assignment
  • Attendance
  • Final paper
  • Presentation
  • Written exam

This page was last modified on:5-4-2024
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