Faculty of Health, Medicine and Life Sciences

Module Information
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MBS1201  - Pathophysiology of Disease

Period 3: from 8-1-2024 to 9-3-2024
Coordinator: Wouters, K.
ECTS credits: 10
Language of instruction: English

Publication dates timetable/results in the Student Portal

Deadline publication timetable
The date on which the timetable of this module is available: 15-12-2023

Deadline publication final result
The date on which the final grade of this module is available: 29-3-2023

Resit booking

Exam booking for a test in current academic year (resit)
You will be booked automatically for the resit in one of our resit periods. You may check our calenders to find out which modules can be retaken and when: https://intranet.maastrichtuniversity.nl/nl/fhml-studenten/studieverloop/wanneer-wat
As of one week before the resit test takes place, you can check in Student Portal if you are booked correctly: Student Portal > My Courses > More actions. The test will also be visible in your time table.

Exam booking for a test from a previous academic year (exam only)
All students who have not passed the test for this module in a previous academic year, will be booked automatically for the test during the regular block period. You will be enrolled in the new course in Canvas but not scheduled for a tutorial group and other educational activities. If you do not wish to participate in this test at the end of the regular block period please de-register via askFHML.

Resit date: 9-7-2024

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Course information

Description: EN:
During the course, an introduction to normal immune system physiology will be given in the form of overview lectures to ensure the same (bachelor) level of knowledge. In addition, during weeks 2 to 7, the focus will be on understanding inflammation during pathophysiology of disease. Every week has a different theme and the students will be challenged with different diseases where immune system dysregulation plays a role. Students will be given their weekly assignments at the beginning of each week, with a prediscussion session where the expected learning goals of the week will be outlined. Thereafter, they will start pre-discussing a case in smaller groups. During the week, they will have expert lectures, e.g. workshops, technical and practical/training skills and journal club discussions. Time will be given for self-study during the week, for both team and individual work. At the end of the week the students will discuss the case they have been working on and the practical/training skill assignment. Theme week 1: Introduction to the immune system: normal physiology. Theme week 2: Innate immunity to bacteria and fungi. Theme week 3: Immunity to viruses. Theme week 4: Sterile inflammation and other pathological threats. Theme week 5: Immunity to tumors. Theme week 6: Hypersensitivity disorders and autoimmunity. Theme week 7: Microbe-host interactions in (immune) homeostasis. Week 8 consists of reflection, poster presentation and exam.
Goals: EN:

B-ILO1202.1 Explain immunity to microbes and viruses

Recognize and compare innate and adaptive immunity to infections

Explain immune evasion by pathogens.

Discuss injurious effects of immune responses: chronic inflammation, septic shock.

 B-ILO1202.2 Explain sterile inflammation and other pathological threats

Analyze the role of sterile inflammation   

Discuss pathological threats such as neurodegeneration, atherosclerosis, ischemia-reperfusion, and cardiometabolic inflammation.

B-ILO1202.3 Explain immunity to tumors

Differentiate tumor immunity, tumor antigens and immune response to tumors.

Explain evasion of the immune response by tumors.

Effects of the tumor microenvironment.

The role of the immune system in promoting tumor growth/tumor progression.

 B-ILO1202.4 Explain hypersensitivity disorders and autoimmunity

Recognize diseases caused by hypersensitivity disorders.

Discuss immunological diseases, their pathogenesis and current therapy. 

Explain IgE and mast cell-dependent reactions and allergic reactions.

 B-ILO1202.5 Explain microbe-host interactions in (immune) homeostasis

Discuss interplay between microbial colonization and the development of the immune system/induction of tolerance

Recognize the induction of (innate) immune responses by microbes at mucosal interfaces

Know how microbiota regulates metabolic and immune homeostasis

Recognize microbial dysbiosis and its role in immune-mediated disease predisposition

Key words: EN:
Pathophysiology/Animal models Infections: virus, bacteria, fungi Sterile inflammation Microbiota Metastasis, tumor evasion Innate/Adaptive immune responses Auto-antibodies/Autoimmunity Allergy
Literature: This is the link to Keylinks, our online reference list.  
Teaching methods:
  • Assignment(s)
  • Work in workgroup(s)
  • Lecture(s)
  • Paper(s)
  • Problem Based Learning
  • Presentation(s)
  • Research
  • Skills
Assessments methods:
  • Assignment
  • Attendance
  • Participaion
  • Presentation
  • Written exam

This page was last modified on:5-4-2024
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