Faculty of Health, Medicine and Life Sciences

Module Information
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MBS1101  - Advanced Principles of Genetics and Genomics

Period 3: from 8-1-2024 to 9-3-2024
Coordinator: Eijssen, L.
ECTS credits: 10
Language of instruction: English

Publication dates timetable/results in the Student Portal

Deadline publication timetable
The date on which the timetable of this module is available: 15-12-2023

Deadline publication final result
The date on which the final grade of this module is available: 29-3-2023

Resit booking

Exam booking for a test in current academic year (resit)
You will be booked automatically for the resit in one of our resit periods. You may check our calenders to find out which modules can be retaken and when: https://intranet.maastrichtuniversity.nl/nl/fhml-studenten/studieverloop/wanneer-wat
As of one week before the resit test takes place, you can check in Student Portal if you are booked correctly: Student Portal > My Courses > More actions. The test will also be visible in your time table.

Exam booking for a test from a previous academic year (exam only)
All students who have not passed the test for this module in a previous academic year, will be booked automatically for the test during the regular block period. You will be enrolled in the new course in Canvas but not scheduled for a tutorial group and other educational activities. If you do not wish to participate in this test at the end of the regular block period please de-register via askFHML.

Resit date: 9-7-2024

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Course information

Description: EN:

The genome is the fundament of life. In this course, various aspects of the composition of the genome will be addressed, such as unique vs repetitive DNA and transcribed vs non-transcribed segments. Another important aspect is the dynamic nature of the genome, especially in regard to epigenetic modification and of the various types of genetic variation. Epigenetic responses and genetic variation partly underlie complex traits and explain the individual susceptibility to influences from the environment.

In this course the molecular mechanisms of genetic and environmental influences on gene expression and protein function are addressed with special attention for deviation from Mendelian inheritance as well as complex regulatory mechanisms in case of both single-gene and multifactorial traits and disorders.

Considerable attention in this course goes to analytical methods for genomics and genetics. A technological revolution has taken place since the start of the unravelling of the human genome, leading to the development of techniques to rapidly sequence a complete genome, but also to perform functional analysis of gene expression and protein function and to incorporate the influence of genetic variation and epigenetic modification into these expression data.

These technological applications lead to huge amounts of data demanding specific algorithms for data analysis to be developed by researchers working in bioinformatics. Throughout the course students will obtain experience with several such algorithms, databases and analytical programs available in the public domain.

Finally, the large increase in knowledge on genomics and genetics together with the still growing potential of analytical possibilities impact research, society and the individual’s way of life. A time slot in the course will be reserved to discuss these developments.
Goals: EN:

In this course we address advanced principles of Genetics and Genomics according to specific Themes, which correspond with the Intended Learning Outcomes (ILOs). For each Theme there will be tutorial sessions, a journal club, an expert lecture and career-related sessions, in which researchers will explain the research that they are performing. During site visits students will go to some of the laboratories for genetics and genomics to get insight into the technological requirements for genetic and genomics in daily practice. In addition, several computer sessions are scheduled to introduce and train students in data handling and analysis. Finally, students are requested to write an essay on a specific topic of genetics or genomics. The ILOs of this course are:

  • Describe human genetic diversity and its dynamics based on the principles of population genetics.- ILO1
  • Integrate the influence of epigenetics with the fundamental regulation of gene expression. ILO2
  • Explain the impact of genetic variation on gene expression and protein function.- ILO3
  • Explain deviations from fundamental genetics in eukaryotes.- ILO4
  • Apply advanced analytical methods of genetics and genomics. - ILO5
  • Analyze data handling in genetics and genomics. - ILO6
  • Define ethical and societal issues concerning genetics and genomics.- ILO7

Key words: EN:
advanced genetics genomics bioinformatics epigenetics gene-environment interaction gene expression analytical techniques data handling/analysis ethical/societal issues
Literature: This is the link to Keylinks, our online reference list.  
Teaching methods:
  • Assignment(s)
  • Lecture(s)
  • Paper(s)
  • Problem Based Learning
  • Skills
  • Working visit(s)
Assessments methods:
  • Assignment
  • Final paper
  • Participaion
  • Written exam

This page was last modified on:22-8-2017
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