Faculty of Health, Medicine and Life Sciences

Module Information
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EPI4923  - Advanced Statistical Analysis Techniques

Period 2: from 26-10-2026 to 18-12-2026 (maandag 26 oktober 2026 tot vrijdag 18 december 2026)
Co-requisites:
None
Coordinator: Innocenti, F.
ECTS credits: 6
Language of instruction: English

Publication dates timetable/results in the Student Portal

Deadline publication timetable
The date on which the timetable of this module is available: not applicable

Deadline publication final result



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Course information

Description: EN:

Advanced Statistical Analysis Techniques covers main statistical techniques used in epidemiological research. In epidemiology, many studies examine relationships between two variables, often interpreted as cause and effect. Analysis depends on measurement type: correlation or regression for quantitative variables, cross-tabulation for qualitative variables, and tests for differences in means or proportions for mixed types. Simple analyses may be insufficient due to confounding or interaction effects. Advanced methods, including regression, ANOVA, and survival analysis, enable analysis of multiple variables in relation to one outcome. Repeated measurements on the same subject require methods that account for their correlation. This can be done with linear mixed models or marginal models for multiple time points, while a single pre-post measurement can be analyzed using ANCOVA (adjusting for the baseline) or ANOVA on the change scores, depending on whether the study is experimental or observational.

Goals: EN:

Knowledge and understanding

  • Understand and apply multivariable statistical methods in epidemiological research, focusing on interpretation rather than mathematical derivations.
  • Understand ANOVA/ANCOVA, including confounding, interaction, assumptions, model hierarchy, and multiple testing corrections (Bonferroni, Tukey).
  • Interpret output from statistical software (e.g., SPSS/R).
  • Understand multiple linear regression, including dummy coding, confounding, interaction, collinearity (VIF/tolerance), and model diagnostics.
  • Recognize repeated measures analysis methods, including marginal models and random effects models, and their assumptions and interpretation.
  • Understand logistic regression for binary outcomes, including odds ratios, estimation methods, model building, interaction, and interpretation.
  • Understand survival analysis methods, including Kaplan-Meier curves, log-rank tests, Cox regression, hazard ratios, censoring, and model selection (AIC/BIC).

Applying knowledge and understanding

  • Independently apply appropriate statistical methods in epidemiological research based on design, variables, and research questions.
  • Develop statistical analysis plans as part of study protocols.
  • Critically interpret statistical methods in scientific literature and conference presentations.

Making judgments

  • Critically evaluate statistical analyses in published epidemiological research.

Communication

  • Communicate statistical concepts and results to both expert and non-expert audiences.

Learning skills

  • Continuously expand statistical knowledge and skills toward more advanced and specialized methods through study or self-directed learning.
Key words: EN:
analysis of (co)variance linear regression logistic regression survival analysis analysis of repeated measures
Literature:

For those using SPSS: Field, A. Discovering statistics using IBM SPSS statistics; 6th ed. London: Sage Publications Ltd, 2024.

For those using R: Field A. Miles J., Field Z. Discovering statistics using R; London: Sage Publications Ltd, 2012.

Link to literature

Teaching methods:
  • Assignment(s)
  • Lecture(s)
  • Problem Based Learning
  • Training(s)
Assessments methods:
  • Attendance
  • Participaion
  • Written exam

This page was last modified on:vrijdag 22 mei 2026
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