Faculty of Health, Medicine and Life Sciences

Module Information
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BBS3024  - Infection and Immunity

Period 2: from 30-10-2023 to 22-12-2023
Coordinator: Penders, J.
ECTS credits: 12
Language of instruction: English

Publication dates timetable/results in the Student Portal

Deadline publication timetable
The date on which the timetable of this module is available: 13-10-2023

Deadline publication final result
The date on which the final grade of this module is available: 17-1-2024

Resit booking

Exam booking for a test in current academic year (resit)
You will be booked automatically for the resit in one of our resit periods. You may check our calenders to find out which modules can be retaken and when: https://intranet.maastrichtuniversity.nl/nl/fhml-studenten/studieverloop/wanneer-wat
As of one week before the resit test takes place, you can check in Student Portal if you are booked correctly: Student Portal > My Courses > More actions. The test will also be visible in your time table.

Exam booking for a test from a previous academic year (exam only)
All students who have not passed the test for this module in a previous academic year, will be booked automatically for the test during the regular block period. You will be enrolled in the new course in Canvas but not scheduled for a tutorial group and other educational activities. If you do not wish to participate in this test at the end of the regular block period please de-register via askFHML.

Resit date: 15-2-2024

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Course information

Description: EN:

While pathogenic microorganisms cause infections and evoke pro-inflammatory immune responses, billions of commensal microorganisms live in symbiosis with their host. This raises various intriguing questions on the delicate interactions between the immune system and the plethora of microorganisms that we as a host encounter.  How can our (mucosal) immune system maintain peace with trillions of commensal microbes, while keeping pathogens at bay? What is the role of the commensals in providing protection against pathogens and in training our immune system? What are the immunological health consequences of loss of microbial biodiversity? How do pathogens evolve to evade our immune system and cause disease? Which options do we currently have to treat or prevent infectious diseases and what are potential future personalized treatment strategies?

In this course these bi-directional host-microbe interactions during homeostasis and infection will be analysed and compared. 

Basic challenges (cases) will be alternated by convince-the-expert meetings during which various host-microbe interactions will be discussed with experts in the fields of immunology, microbiology and infectious diseases. In addition you will be working on an academic group project in which the gained knowledge will be applied to develop a future solution to tackle microbe-mediated diseases. The results of the academic project will be presented during a final symposium at the end of the course.

Within this course there will also be several skills trainings to study. This includes a training on mucosal immunological tissues. Moreover, you will have the opportunity to design and conduct your own intervention study to modify your own oral microbiome.

Goals: EN:

       · To evaluate future solutions to treat and prevent deleterious infections and microbiome-mediated diseases

       · To compare current strategies for the therapeutic treatment of infections by targeting the microbe or supporting the       immune system 

       · To analyze the processes by which the immune system in response to an infection leads to pathology, and the consequences of failing to control infection

       · To distinguish how the host’s immune system discriminates between various microbes, and commensal vs. pathogenic bacteria

       · To examine what determines microbial virulence and how commensals can turn into pathogens

       · To understand the various microbial ecosystems in the human body and explain their role in maintaining human health and to analyze the link between lost microbial exposure and the rise in non-communicable/communicable diseases.

Key words: EN:
Mucosal Immunology, Microbiome, Host-Microbe interactions, Innate immune system, Adaptive immune system, Microbiology, Bacteria, Antimicrobial therapy, Fecal Microbiota Transplantation, Vaccination, Virulence
Literature: This is the link to Keylinks, our online reference list.  
Teaching methods:
  • Assignment(s)
  • Work in workgroup(s)
  • Lecture(s)
  • Problem Based Learning
  • Presentation(s)
  • Research
  • Skills
Assessments methods:
  • Presentation
  • Written exam

This page was last modified on:6-4-2024
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