Faculty of Health, Medicine and Life Sciences

Module Information
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BBS3014  - Immune Responses in Health and Disease

Period 1: from 4-9-2023 to 27-10-2023
Coordinator: Gaens, K.
ECTS credits: 12
Language of instruction: English

Publication dates timetable/results in the Student Portal

Deadline publication timetable
The date on which the timetable of this module is available: 18-8-2023

Deadline publication final result
The date on which the final grade of this module is available: 17-11-2023

Resit booking

Exam booking for a test in current academic year (resit)
You will be booked automatically for the resit in one of our resit periods. You may check our calenders to find out which modules can be retaken and when: https://intranet.maastrichtuniversity.nl/nl/fhml-studenten/studieverloop/wanneer-wat
As of one week before the resit test takes place, you can check in Student Portal if you are booked correctly: Student Portal > My Courses > More actions. The test will also be visible in your time table.

Exam booking for a test from a previous academic year (exam only)
All students who have not passed the test for this module in a previous academic year, will be booked automatically for the test during the regular block period. You will be enrolled in the new course in Canvas but not scheduled for a tutorial group and other educational activities. If you do not wish to participate in this test at the end of the regular block period please de-register via askFHML.

Resit date: 14-2-2024

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Course information

Description: EN:

The immune system is a remarkable natural system that is proving to be of great inspiration to scientists, medical staff and students. It is ubiquitous in present life. This course provides a detailed study of the functioning of the immune system. Students acquire insights into the molecular and cellular interactions and functioning of the immune system in normal conditions. Topics include the development of immune cells, humoral and cell-mediated immunity, and tolerance. During the past decades, evidence has mounted that many (chronic) diseases are characterized by an imbalance of the immune system. Moreover, we are challenged by complex situations where it is demonstrated that the immune system plays a crucial role. Therefore, the role of the immune system in a variety of diseases and complex situations (e.g. cancer, autoimmunity, neurodegenerative diseases, microbial defense, transplantation and vaccination) will be studied in an integrated way during the project week and integration assignment. 

This course provides a detailed study of the function of the immune system and previous/basic knowledge of the immune system is assumed/recommended for this course. 

Goals: EN:

ILO3014.1 Explain the structure and function of lymphoid organs and the development of leucocytes:

a) Describe and draw lymphoid organs and relate the structure of lymphoid organs to their function.

b) Explain the development of innate immune cells. 

c) Explain the development and maturation of adaptive immune cells. 

d) Explain the migration pathways of leucocytes in the body (during homeostasis and disease/infection).


ILO3014.2 Analyze the activation and downregulation of innate and adaptive immune responses:

a) Compare the innate and the adaptive immune system during sterile and non-sterile inflammation.

b) Explain the genetic base and diversity of MHC molecules and their role in disease.

c) Examine the immune regulation mechanisms of the immune system.


ILO 3014.3 Explain the roles of immune cells in the innate and adaptive immune systems in health:

a) Explain in time (4D), order, and function

b) Gender diversity and aging

c) Influence of nutrition/environment


ILO 3014.4 Understand and present the immune processes underlying immune relatedpathophysiology:

a) Hypersensitivity (incl allergy and autoimmunity)

b) Immunodeficiency

c) Cancer


ILO 3014.5 Understand and present strategies to modulate immune responses to improve human health:

a) Design a plan to translate an invention from research to clinical application.


ILO 3014.6 Explain techniques commonly used to investigate the phenotype and functionof cells in immune responses:

a) Students know the basic principles and applications of serological and cellular immune tests and can correctly analyze and interpret the results. 

b) Students understand the selection and application of practical immunological approaches to conduct an investigation.


Key words: EN:
Development of immune system Humoral and cell-mediated immunity Tolerance Immune-related conditions Immunological therapies
Literature: This is the link to Keylinks, our online reference list.  
Teaching methods:
  • Assignment(s)
  • Work in workgroup(s)
  • Lecture(s)
  • Paper(s)
  • Problem Based Learning
  • Presentation(s)
  • Skills
Assessments methods:
  • Assignment
  • Attendance
  • Final paper
  • Participaion
  • Presentation
  • Written exam

This page was last modified on:16-4-2024
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